Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep810 | Obesity | ECE2016

A body-wide transcriptome screen reveals high ghrelin gene (GHRL) expression in monocytes and supports a hypothesis of monocyte GHRL-derived hormones as critical mediators of the brain-gut axis and monocyte-adipocyte cross-talk in health and obesity

Seim Inge , Crisp Gabrielle , Jeffery Penelope , Chopin Lisa

Introduction: It is now appreciated that peptide hormones encoded by the ghrelin gene, GHRL, have roles in many biological systems and cell types. In particular, the hormone ghrelin is a therapeutic target and clinical marker for a range of pathologies, including diet-induced and genetic obesity. High-quality transcriptome (RNA-seq) data sets generated by consortia, such as the Human Protein Atlas (HPA) and Encyclopedia of DNA Elements (ENCODE), now offer an opportuni...